Original paper

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Volume: 11, Issue: 1
Published: Oct 7, 2020
Abstract
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electrophile and non-covalent fragments through a combined mass spectrometry and X-ray approach against the SARS-CoV-2 main protease, one...
Paper Details
Title
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Published Date
Oct 7, 2020
Volume
11
Issue
1
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