CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage

Background Recent genomic profiling has identified a subtype of prostate cancer (PCa) characterized by two key genetic alterations: missense mutation of speckle‐type POZ protein ( SPOP ) and homozygous deletion of chromodomain helicase DNA‐binding protein 1 ( CHD1 ). Mutually exclusive with E26 transformation‐specific ( ETS ) rearrangements, this subtype displays high genomic instability. Previous studies indicate that deficient SPOP or CHD1...