Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders.

Published on Sep 26, 2020in World Journal of Stem Cells3.231
· DOI :10.4252/WJSC.V12.I9.986
Jian-Qun Wu , Nan Jiang11
Estimated H-index: 11
(Southern Medical University)
+ 0 AuthorsBin Yu18
Estimated H-index: 18
(Southern Medical University)
#1Xiaomin Kang (Xi'an Jiaotong University)H-Index: 8
#2Zhuang Qian (Xi'an Jiaotong University)H-Index: 6
Last. Shufang Wu (Xi'an Jiaotong University)H-Index: 15
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Neuropeptide Y (NPY) is known to regulate bone homeostasis; however, its functional role as a risk factor during osteoarthritis (OA) remains elusive. In this study, we aim to investigate the direct effect of NPY on degradation of cartilage and progression of OA and explore the molecular events involved. NPY was overexpressed in human OA cartilage accompanied with increased expression of NPY1 receptor (NPY1R) and NPY2 receptor (NPY2R). Stressors such as cold exposure resulted in the peripheral re...
1 CitationsSource
#1Baris Ulum (METU: Middle East Technical University)H-Index: 3
#1Baris Ulum (Hacettepe University)H-Index: 1
Last. Fatima Aerts-Kaya (Hacettepe University)H-Index: 4
view all 6 authors...
Abstract Differentiation, self-renewal and quiescence of Hematopoietic stem cells (HSCs) is tightly regulated in order to protect the HSCs from the strain of constant cell division and depletion of the stem cell pool. The neurotransmitter Neuropeptide Y (NPY) is released from sympathetic nerves in the bone marrow and has been shown to indirectly affect HSC function through effects on bone marrow (BM) multipotent Mesenchymal Stromal Cells (MSCs), osteoblasts (OBs) and macrophages. Although the ab...
4 CitationsSource
#1Ruixin Chen (SYSU: Sun Yat-sen University)H-Index: 1
#2Zhichao Hao (SYSU: Sun Yat-sen University)H-Index: 1
Last. Yuanyuan Ma (SYSU: Sun Yat-sen University)H-Index: 9
view all 5 authors...
Abstract In recent years, emerging evidence has illustrated the indispensable role of sympathetic neurotransmitters and their receptors in cartilage mediation. The presence of neuropeptide Y (NPY)-positive sympathetic nerve fibres in cartilage and NPY-secretion function in chondrocytes raises the possibility of NPY directly regulating the function of chondrocytes. Therefore, this study intended to evaluate the effect of NPY and its receptors on the proliferation and chondrogenic differentiation ...
1 CitationsSource
#1Fatima Aerts-Kaya (RMIT: RMIT University)H-Index: 4
#2Baris Ulum (Hacettepe University)H-Index: 3
Last. Duygu Uçkan-Çetinkaya (RMIT: RMIT University)H-Index: 4
view all 7 authors...
The bone marrow (BM) hematopoietic niche is the microenvironment where in the adult hematopoietic stem and progenitor cells (HSPCs) are maintained and regulated. This regulation is tightly controlled through direct cell-cell interactions with mesenchymal stromal stem (MSCs) and reticular cells, adipocytes, osteoblasts and endothelial cells, through binding to extracellular matrix molecules and through signaling by cytokines and hematopoietic growth factors. These interactions provide a healthy e...
5 CitationsSource
#1Alexandra O. Luby (UM: University of Michigan)H-Index: 1
#2Kavitha RanganathanH-Index: 18
Last. Steven R. BuchmanH-Index: 25
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AbstractMesenchymal stem cells (MSCs) are capable of differentiating into osteoblasts, chondrocytes, and adipocytes, each of which is important for musculoskeletal tissue regeneration and repair. Reconstruction and healing of bony defects remains a major clinical challenge. Even as surgical practice
8 CitationsSource
#1L Praveen Kumar (Vels University)H-Index: 1
#2Sangeetha Kandoi (Indian Institute of Technology Madras)H-Index: 3
Last. Rama Shanker Verma (Indian Institute of Technology Madras)H-Index: 25
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Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound healing is essentially based on their paracrine effects. Numerous pre-clinical and clinical studies of MSCs have yielded encouraging results. Further, these cells have been shown to be relatively safe for clinical applications. MSCs harvested from numerous anatomical locations including the bone marrow, adipose tissue, Whart...
51 CitationsSource
#1Birgitta Gatenholm (University of Gothenburg)H-Index: 3
#2Mats Brittberg (University of Gothenburg)H-Index: 37
Purpose This review explores the mechanisms of joint pain with a special focus on the role of neuropeptides in pain transmission and their potential role in the progression of joint degeneration as seen in osteoarthritis.
3 CitationsSource
#1Prathap Jayaram (BCM: Baylor College of Medicine)H-Index: 7
#2Uzoh E. Ikpeama (BCM: Baylor College of Medicine)H-Index: 1
Last. Gerard A. Malanga (RU: Rutgers University)H-Index: 22
view all 4 authors...
Abstract Regenerative medicine in the context of musculoskeletal injury is a broad term that offers potential therapeutic solutions to restore or repair damaged tissue. The current focus in recent literature and clinical practice has been on cell based therapy. In particular, much attention has been centered on autologous bone marrow concentrate (BMAC) and adipose-derived (AD) mesenchymal stem cells (MSCs) for cartilage and tendon disorders. This article provides an overview of MSC-derived thera...
23 CitationsSource
#1Natalie K.Y. WeeH-Index: 9
#2Benjamin P. SinderH-Index: 11
Last. Ivo KalajzicH-Index: 34
view all 7 authors...
Abstract Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which cells within the skeleton express Npy and establish a model that will enable us to differentiate effects of NPY derived from different cell types. We have generated the NPY f...
11 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#1Rita Businaro (Sapienza University of Rome)H-Index: 6
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
view all 14 authors...
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the pres...
8 CitationsSource
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