Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders.

Published on Sep 26, 2020in World Journal of Stem Cells3.231
· DOI :10.4252/WJSC.V12.I9.986
Jian-Qun Wu , Nan Jiang11
Estimated H-index: 11
(Southern Medical University)
+ 0 AuthorsBin Yu18
Estimated H-index: 18
(Southern Medical University)
Source
Abstract
References98
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Neuropeptide Y (NPY) is known to regulate bone homeostasis; however, its functional role as a risk factor during osteoarthritis (OA) remains elusive. In this study, we aim to investigate the direct effect of NPY on degradation of cartilage and progression of OA and explore the molecular events involved. NPY was overexpressed in human OA cartilage accompanied with increased expression of NPY1 receptor (NPY1R) and NPY2 receptor (NPY2R). Stressors such as cold exposure resulted in the peripheral re...
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Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the pres...
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