RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
Abstract
Obesity is a major public health burden worldwide and is characterized by chronic low-grade inflammation driven by the cooperation of the innate immune system and dysregulated metabolism in adipose tissue and other metabolic organs. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a central regulator of inflammatory cell function that coordinates inflammation, apoptosis and necroptosis in response to inflammatory stimuli. Here...
Paper Details
Title
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
Published Date
Sep 28, 2020
Journal
Volume
2
Issue
10
Pages
1113 - 1125
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