Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents
Abstract
While many cellular mechanisms leading to chemotherapeutic resistance have been identified, there is an increasing realization that tumor-stroma interactions also play an important role. In particular, mechanical alterations are inherent to solid cancer progression and profoundly impact cell physiology. Here, we explore the influence of compressive stress on the efficacy of chemotherapeutics in pancreatic cancer spheroids. We find that increased...
Paper Details
Title
Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents
Published Date
Sep 18, 2020
Journal
Volume
125
Issue
12
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