Biosensor

Nanotechnology

Metallurgy

Materials science

Bioadhesive

Biocompatibility

Drug delivery

Graphene

Bioelectronics

Nature Materials

Reliable functions of bioelectronic devices require conformal, stable and conductive interfaces with biological tissues. Integrating bioelectronic devices with tissues usually relies on physical attachment or surgical suturing; however, these methods face challenges such as non-conformal contact, unstable fixation, tissue damage, and/or scar formation. Here, we report an electrical bioadhesive (e-bioadhesive) interface, based on a thin layer of a graphene nanocomposite, that can provide rapid (adhesion formation within 5 s), robust (interfacial toughness &gt;400 J m−2) and on-demand detachable integration of bioelectronic devices on diverse wet dynamic tissues. The electrical conductivity (&gt;2.6 S m−1) of the e-bioadhesive interface further allows bidirectional bioelectronic communications. We demonstrate biocompatibility, applicability, mechanical and electrical stability, and recording and stimulation functionalities of the e-bioadhesive interface based on ex vivo porcine and in vivo rat models. These findings offer a promising strategy to improve tissue–device integration and enhance the performance of biointegrated electronic devices. A graphene nanocomposite hydrogel showing anisotropic swelling is used to realize an electrically conducting and removable bioadhesive that improves the mechanical and electrical integration of bioelectronics devices with wet dynamic tissues.

Electrical bioadhesive interface for bioelectronics