SHP2 knockdown ameliorates liver insulin resistance by activating IRS‐2 phosphorylation through the AKT and ERK1/2 signaling pathways
Abstract
Diabetes is a chronic metabolic disease characterized by insulin resistance (IR). SHP2 has previously been identified as a potential target to reduce IR in diabetes. Here, we examined the effects of SHP2 on glucose consumption (GC), IR level and the expression of insulin receptor substrate (IRS), AKT and extracellular signal-regulated kinase (ERK)1/2 proteins in a cellular and animal model of diabetes. IR was induced in hepatocellular carcinoma...
Paper Details
Title
SHP2 knockdown ameliorates liver insulin resistance by activating IRS‐2 phosphorylation through the AKT and ERK1/2 signaling pathways
Published Date
Nov 3, 2020
Journal
Volume
10
Issue
12
Pages
2578 - 2587
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