Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance
Abstract
Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes. Here, we report on a monogenic form of IR-prone obesity, Alström syndrome (ALMS). Twenty-three subjects with monogenic or polygenic obesity underwent hyperinsulinemic-euglycemic clamping with concomitant adipose tissue (AT)...
Paper Details
Title
Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance
Published Date
Sep 29, 2020
Journal
Volume
70
Issue
2
Pages
364 - 376
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