Metal‐Catalyzed Spiroannulation‐Fluoromethylfunctionaliztions of 1,5‐Enynes for the Synthesis of Stereodefined (Z)‐Spiroindenes

Two classes of new catalytic spiroannulation‐fluormethylfunctionaliztions of para ‐quinone methide ( p ‐QM)‐containing 1,5‐enynes have been established under redox‐neutral conditions. Palladium‐catalyzed spiroannulation‐iododifluoromethylation with ethyl difluoroiodoacetate oriented completely stereoselective access to ( Z )‐spiroindenes and the latter included copper‐catalyzed three‐component spiroannulation‐cyanotrifluoromethylation starting...