Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD

Volume: 14, Issue: 2, Pages: 431 - 442
Published: Mar 1, 2021
Abstract
Although activation of adaptive immunity is a common pathological feature of chronic obstructive pulmonary disease (COPD), particularly during later stages of the disease, the underlying mechanisms are poorly understood. In small airways of COPD patients, we found that localized disruption of the secretory immunoglobulin A (SIgA)-containing mucosal immunobarrier correlated with lymphocyte accumulation in airway walls and development of tertiary...
Paper Details
Title
Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD
Published Date
Mar 1, 2021
Volume
14
Issue
2
Pages
431 - 442
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