LBA17 ASCENT: A randomized phase III study of sacituzumab govitecan (SG) vs treatment of physician’s choice (TPC) in patients (pts) with previously treated metastatic triple-negative breast cancer (mTNBC)

In pts with pretreated mTNBC, standard of care (SOC) chemotherapy is associated with low objective response rates (ORRs) and short median progression-free survival (mPFS). SG (TRODELVY™) is a first-in-class antibody-drug conjugate (ADC) composed of an anti–Trop-2 antibody coupled to the active metabolite of irinotecan, SN-38, via a unique hydrolyzable linker that allows for SN-38 release intracellularly and in the tumor microenvironment...