Cardiovascular disease, psychiatric diagnosis and sex differences in the multistep hypothesis of amyotrophic lateral sclerosis

Background and purpose Amyotrophic lateral sclerosis (ALS) risk increases with age, and a linear log‐incidence and log‐age relationship is interpreted to suggest that five to six factors are involved in disease onset. The factors remain unidentified, except that fewer steps are predicted for those carrying a known ALS‐causing mutation. Methods Men with a psychiatric disorder or cardiovascular disease (CVD) diagnosis have an increased relative...