Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Abstract
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a...
Paper Details
Title
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Published Date
Oct 23, 2020
Journal
Volume
370
Issue
6515
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