Reader Response: White Matter Hyperintensities Mediate the Association of Nocturnal Blood Pressure With Cognition

Chesebro et al.1 report dysfunctional circadian variation of systolic blood pressure—reverse dipping, that is, night/day BP > 1—among the hypertensive subset (mean age 64 years) of their Venezuelan cohort, and they link this to periventricular white matter hyperintensities and decreased memory. In 2019, we reported associations between reverse dipping of diastolic blood pressure and both cerebral microvascular disease and decreased...