Activation of Nell-1 in BMSC Sheet Promotes Implant Osseointegration Through Regulating Runx2/Osterix Axis

Neural epidermal growth factor-like 1 protein (Nell-1) is first studied because of its association with human craniosynostosis. Recently, the osteoinductive ability of Nell-1 is valued, and Nell-1 is used to accelerate the process of fracture healing. However, the role of Nell-1 during the process of osteointegration is unknown. Here we show that activation of Nell-1 in BMSC sheet promotes osseointegration in vivo and in vitro. We found that...