A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Abstract
Background Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies (GWASs). PGS methods differ in which DNA variants are included and the weights assigned to them; some require an independent tuning sample to help inform these choices. PGSs are evaluated in independent target cohorts with known disease status. Variability...
Paper Details
Title
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Published Date
Sep 11, 2020
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