Caution Advised Using Combination Ketoconazole and PD-1 Inhibitors

ObjectiveImmune checkpoint inhibitors are approved to treat multiple cancers. We report life-threatening hepatic failure in 2 consecutive patients with Cushing syndrome that were treated with ketoconazole (KTZ) in combination with 2 different programmed cell death protein 1 (PD-1) inhibitors, Nivolumab and Pembrolizumab.MethodsThe first patient suffered from corticotroph pituitary carcinoma and the second from metastatic adrenal cortical...