PARP Inhibitors in Cancer Diagnosis and Therapy.
Abstract
Targeting of PARP enzymes has emerged as an effective therapeutic strategy to selectively target cancer cells with deficiencies in homologous recombination signaling. Currently used to treat BRCA-mutated cancers, PARP inhibitors (PARPi) have demonstrated improved outcome in various cancer types as single agents. Ongoing efforts have seen the exploitation of PARPi combination therapies, boosting patient responses as a result of drug synergisms....
Paper Details
Title
PARP Inhibitors in Cancer Diagnosis and Therapy.
Published Date
Mar 15, 2021
Journal
Volume
27
Issue
6
Pages
1585 - 1594
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Notes
History