FAM172A Deletion May Enhance Hepatic Steatosis by Promoting ER Stress

Endoplasmic reticulum (ER) stress is one of the major causes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Our previous study showed that maintains the homeostasis of ER could effectively alleviate NAFLD. In this study, we found that the loss of FAM172A increased ER stress. The aims of this study were to explore whether FAM172A could improve NAFLD by inhibiting ER stress. The expression levels of FAM172A and ER stress were...