Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses
Abstract
Interleukin-10 (IL-10) is a dimeric cytokine with both immunosuppressive and immunostimulatory activities; however, IL-10-based therapies have shown only marginal clinical benefits. Here, we explored whether the stability of the IL-10 receptor complex contributes to the immunomodulatory potency of IL-10. We generated an IL-10 mutant with enhanced affinity for its IL-10Rβ receptor using yeast surface display. Compared to the wild-type cytokine,...
Paper Details
Title
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses
Published Date
Sep 15, 2020
Journal
Volume
13
Issue
649
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