UHRF1 Is a Novel Druggable Epigenetic Target in Malignant Pleural Mesothelioma

Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) encodes a master regulator of DNA methylation that has emerged as an epigenetic driver in human cancers. To date, no studies have evaluated UHRF1 expression in malignant pleural mesothelioma (MPM). This study was undertaken to explore the therapeutic potential of targeting UHRF1 in MPM.Microarray, real-time quantitative reverse transcription-polymerase chain reaction,...