De novo lipogenesis is essential for platelet production in humans
Abstract
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for platelet production in humans and monkeys, but in not rodents or dogs. During clinical evaluation of a systemically distributed ACC inhibitor, unexpected dose-dependent reductions in platelet count...
Paper Details
Title
De novo lipogenesis is essential for platelet production in humans
Published Date
Sep 14, 2020
Journal
Volume
2
Issue
10
Pages
1163 - 1178
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