Small molecule compounds promote the proliferation of chondrocytes and chondrogenic differentiation of stem cells in cartilage tissue engineering.

Published on Sep 14, 2020in Biomedicine & Pharmacotherapy4.545
· DOI :10.1016/J.BIOPHA.2020.110652
Tian Li (JLU: Jilin University), Bingzhang Liu (JLU: Jilin University)+ 3 AuthorsDuo Zhang (JLU: Jilin University)
#1Hui GaoH-Index: 1
#2Lu PengH-Index: 1
Last. Ping LiH-Index: 1
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Introduction: Osteoarthritis (OA) is the most common disease, which seriously affects the daily life of the elderly. Currently, no traditional or drug therapy has been shown to explicitly block the progression of OA. Salidroside (Sal) is a bioactive component of Rhodiola rosea, which has many beneficial effects on human health. However, the role and mechanism of Sal in OA have not been reported. Methods: We established an anterior cruciate ligament transection (ACLT)-induced OA Rat model. The ra...
4 CitationsSource
#1Marta Anna Szychlinska (University of Catania)H-Index: 20
#2Giovanna Calabrese (University of Catania)H-Index: 12
Last. Giuseppe Musumeci (University of Catania)H-Index: 45
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Stem cell therapy and tissue engineering represent a promising approach for cartilage regeneration. However, they present limits in terms of mechanical properties and premature de-differentiation of engineered cartilage. Cycloastragenol (CAG), a triterpenoid saponin compound and a hydrolysis product of the main ingredient in Astragalus membranaceous, has been explored for cartilage regeneration. The aim of this study was to investigate CAG’s ability to promote cell proliferation, maintain cells ...
6 CitationsSource
#1João C. Silva (IST: Instituto Superior Técnico)H-Index: 9
#2Ranodhi N. Udangawa (RPI: Rensselaer Polytechnic Institute)H-Index: 7
Last. Robert J. Linhardt (RPI: Rensselaer Polytechnic Institute)H-Index: 95
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Abstract Electrospinning is a valuable technology for cartilage tissue engineering (CTE) due to its ability to produce fibrous scaffolds mimicking the nanoscale and alignment of collagen fibers present within the superficial zone of articular cartilage. Coaxial electrospinning allows the fabrication of core-shell fibers able to incorporate and release bioactive molecules (e.g., drugs or growth factors) in a controlled manner. Herein, we used coaxial electrospinning to produce coaxial poly(glycer...
10 CitationsSource
#1Miao Sun (Guangxi Medical University)H-Index: 1
#2Zhenhui Lu (Guangxi Medical University)H-Index: 8
Last. Jinmin Zhao (Guangxi Medical University)H-Index: 25
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Abstract Autologous chondrocyte implantation (ACI) is commonly used for the treatment of cartilage defects. Since the cell number for transplantation is limited, the expand culture of chondrocytes in vitro is needed. However, the phenotype of chondrocytes is easy to lose in monolayer cultured in vitro. Traditional growth factors such as transformation growth factor -β1 (TGF-β1) have been used for promoting the proliferation and maintained the phenotype of chondrocytes, but the high cost and func...
2 CitationsSource
#1Zheng Chen (SYSU: Sun Yat-sen University)H-Index: 4
#2Yuxuan Wang (HUST: Huazhong University of Science and Technology)
Last. Hong Ai (SYSU: Sun Yat-sen University)H-Index: 3
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Abstract Objective The aim of this study is to investigate the effects of 17β-Estradiol (E2) at different concentrations combined with cyclical compressive stress on the proliferation and differentiation of mandibular condylar chondrocytes (MCCs). Design MCCs, isolated from female Sprague-Dawley rats, were exposed to E2 at different concentration, cyclical compressive stress or the combination, effects of which on MCCs proliferation and differentiation were detected. Results E2 at physiological ...
1 CitationsSource
#1Pengzhen Wang (JNU: Jinan University)H-Index: 2
#2Xifeng Xiong (JNU: Jinan University)H-Index: 5
Last. Zhihe Liu (JNU: Jinan University)H-Index: 10
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Abstract Background Articular cartilage is a unique avascular tissue in which chondrocytes are embedded in extracellular matrix (ECM). The decreased ECM resulting from the loss of articular chondrocyte viability leads to degenerative diseases such as osteoarthritis (OA). This study aims to investigate the effect of icariin (ICA) on ECM synthesis and chondrocyte viability. Methods Micromass culture, alcian blue, and Safran O (SO)/fast green staining were used to investigate chondrocyte viability ...
6 CitationsSource
#1Mona Gorji (IUMS: Isfahan University of Medical Sciences)
Last. Batool Hashemibeni (IUMS: Isfahan University of Medical Sciences)H-Index: 14
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Background: Nowadays, cartilage tissue engineering is the best candidate for regeneration of cartilage defects. This study evaluates the effect of fibrin/icariin (ICA) nanoparticles (F/I NPs) on chondrogenesis of stem cells. Materials and Methods: F/I NPs were characterized by Dynamic Light Scattering DLS. Poly (lactic-co-glycolic) acid (PLGA)-F/I NP scaffold was fabricated and assessed by scanning electron microscope. Human adipose-derived stem cells (hADSCs) were seeded on scaffold and induced...
2 CitationsSource
#1Ghazal Keshavarz (Kermanshah University of Medical Sciences)H-Index: 1
#2Cyrus Jalili (Kermanshah University of Medical Sciences)H-Index: 10
Last. Mozafar Khazaei (Kermanshah University of Medical Sciences)H-Index: 17
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Purpose: Adipose stem cells (ASCs) are pluripotent cells with the ability of self-renewal anddifferentiation into different types of mesenchymal cells. As cartilage repair is difficult due tolack of blood capillary, resveratrol (Res) is a polyphenolic compound with diverse biologicalproperties to be possibly used in this case. The aim of the present study was to investigate theeffect of Res on differentiation of ASCs into chondrocyte in a three-dimensional (3D) culturemodel.Methods: Subcutaneous...
4 CitationsSource
#1Shi ZuoH-Index: 3
#2Wei ZouH-Index: 1
Last. Hai-Yang LiH-Index: 3
view all 7 authors...
Objective: Osteoarthritis (OA) is characterized by progressive matrix destruction of articular cartilage. This study aimed to investigate the potential antioxidative and chondroprotective effects and underlying mechanism of Icariin (ICA) in interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation of OA cartilage. Methods: Human chondrocyte cell line HC-A was treated with different doses of ICA, and then MTT assay and PI staining were used to estimate ICA-induced chondrocyte apop...
6 CitationsSource
#1Seon-Mi Yu (UPR-RP: UPRRP College of Natural Sciences)H-Index: 7
#2Yohan Han (UPR-RP: UPRRP College of Natural Sciences)H-Index: 3
Last. Song Ja Kim (UPR-RP: UPRRP College of Natural Sciences)H-Index: 27
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Abstract Simvastatin is widely used as a specific inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase to reduce the levels of low-density lipoprotein cholesterol. However, its regulatory mechanism in chondrocyte differentiation is unclear. This study was conducted to evaluate the effects and signalling pathway of simvastatin on chondrocyte differentiation. We found that simvastatin induced chondrocyte differentiation, as confirmed by increased type II collagen expression and induced sulphated...
1 CitationsSource
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