AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models

Volume: 26, Issue: 21, Pages: 5735 - 5746
Published: Nov 1, 2020
Abstract
Purpose: Medulloblastoma is an important cause of mortality and morbidity in pediatric oncology. Here, we investigated whether the DNA repair inhibitor, AsiDNA, could help address a significant unmet clinical need in medulloblastoma care, by improving radiotherapy efficacy without increasing radiation-associated toxicity. Experimental Design: To evaluate the brain permeability of AsiDNA upon systemic delivery, we intraperitoneally injected a...
Paper Details
Title
AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models
Published Date
Nov 1, 2020
Volume
26
Issue
21
Pages
5735 - 5746
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