A combination of hydrogen bonding and chemical covalent crosslinking to fabricate a novel swim-bladder-derived dry heart valve material yields advantageous mechanical and biological properties.

Published on Feb 13, 2021in Biomedical Materials3.174
· DOI :10.1088/1748-605X/ABB616
Xiaorong Lan5
Estimated H-index: 5
(Sichuan University),
Lan Xiaorong + 2 AuthorsYunbing Wang15
Estimated H-index: 15
Source
Abstract
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Glutaraldehyde (GA) crosslinked bovine or porcine pericardium tissues exhibit high cell toxicity and calcification in the construction of bioprosthetic valves, which accelerate the failure of valve leaflet and motivate the exploration for alternatives. Polyphenols, including curcumin, procyanidin and quercetin etc., have showed great calcification inhibition potential in crosslinking collagen and elastin scaffolds. Herein, we developed an innovative phenolic fixing technique by using curcumin as...
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Calcification is a major cause of cardiovascular materials failure and deterioration, which leads to the restriction of their wide application. To develop new materials with anti-calcification capability is an urgent clinical requirement. Herein, a natural material derived from swim bladders as one promising candidate is introduced, which is prepared by decellularization and glutaraldehyde (GA) crosslinking. Data show that the swim bladder is mainly composed of collagen I, glycosaminoglycan (GAG...
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: The failures of glutaraldehyde (GLUT) cross-linked bioprosthetic heart valves (BHVs) are mainly due to degeneration and calcification. In this study, we developed a new preparation strategy for BHVs named as "HPA/EDC/EGCG" that utilized 3,4-hydroxyphenylpropionic acid (HPA)-conjugated pericardium, epigallocatechin gallate (EGCG), and horseradish peroxidase (HRP)/hydrogen peroxide (H2 O2 ) enzymatic cross-linking. HPA-pericardium conjugation was done by carbodiimide coupling reaction using 1-et...
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: Bioprosthetic heart valves (BHVs) used in the clinic are mostly fixed by glutaraldehyde and the lack of endothelialization is a major problem for glutaraldehyde-fixed pericardia. Hyaluronic acid is a major glycosaminoglycan that exists in native heart valves. Coupled with its inherent biocompatibility, it may enhance endothelial adhesion and proliferation when associated with vascular endothelial growth factor (VEGF). In this study, an optimized system is developed to improve the endothelializ...
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Objective: To investigate the potential restorative effects of the white fish (Rutilus frisii kutum) swim bladder matrix (FSBM) treated with hyaluronic acid (HA) in the repair of skin wounds in an animal model. Method: Wistar rats were used to investigate the repair function of FSBM as a biological scaffold. Rats were given four round wounds on their back. Wounds were divided into four groups: control, acellular fish swim bladder matrix (AFSBM), HA and AFSBM impregnated with HA (AFSBM-HA). Macro...
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Transcatheter aortic valve implantation (TAVI) has been developed years ago for patients who cannot undergo a surgical aortic valve replacement (SAVR). Although TAVI possesses the advantages of lower trauma and simpler manipulation compared to SAVR, the need for storage in glutaraldehyde (GLU) and a tedious intraoperative assembly process have caused great inconvenience for its further application. A pre-mounted TAVI valve assembled by mounting a dry valve frame to a delivery system is expected ...
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Thrombosis and infections of extracorporeal circuits and indwelling medical devices are the two major life-threatening complications faced in clinical practice. Herein, we report a novel and facile metal–phenolic–amine surface modification strategy to engineer a multifunctional coating on these devices to combat thrombosis and infection. This strategy is inspired by the metal–catecholamine coordination complex of [Fe(dopa)3] in mussels, in which Cu(II) ions (metal), plant polyphenol gallic acid ...
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ABSTRACTObjectives: This paper aimed to develop a novel dura mater substitute made from swim bladders.Methods: The swim bladders were decellularized by diverse methods. The physical structure, residual DNA amount, mechanical properties and hemolysis rate were tested. The in vitro mouse embryonic fibroblast cells (MEFs) co-culture and in vivo dural repair surgery were performed to evaluate the biocompatibility of acellular swim bladder (ASBs).Results: The characteristics of different ASBs were ev...
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Abstract Decellularized porcine heart valves offer promising potential as biocompatible prostheses. However, this procedure alter matrix fibres and glycans, leading to lower biomechanical resistance and increased their thrombotic potential. Therefore, their durability is limited due to calcification and weak regeneration in vivo . Surface modifications are highly requested to improve the scaffolds re-endothelialization required to restore functional and haemocompatible heart valve. Fucoidan, a n...
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Abstract Flexure is an important mode of deformation for native and bioprosthetic heart valves. However, mechanical characterization of bioprosthetic leaflet materials has been done primarily through planar tensile testing. In this study, an integrated experimental and computational cantilever beam bending test was performed to characterize the flexural properties of glutaraldehyde-treated bovine and porcine pericardium of different thicknesses. A strain-invariant based structural constitutive m...
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