Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

Volume: 52, Issue: 10, Pages: 1122 - 1131
Published: Sep 7, 2020
Abstract
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here we estimated the effects of 1,002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 130 (31.5%) were not supported by results of...
Paper Details
Title
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Published Date
Sep 7, 2020
Volume
52
Issue
10
Pages
1122 - 1131
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