Abstract 5086: The aged tumor microenvironment promotes melanoma metabolic plasticity and therapy

“Aged” melanoma patients (>55 years old) have poorer prognosis and reduced response rates to targeted therapy relative to “young” patients (<40 years old). Here, we report an altered metabolic landscape in the aged tumor microenvironment (TME) as critical for melanoma aggressiveness. Aged fibroblasts uptake high levels of glucose compared to their young counterparts, which fuels lipid production. Melanoma cells cultured in an aged...