Abstract 5098: Cues from extracellular matrix produced by fibroblasts prime lung cancer cells for distant dissemination

Extracellular matrix (ECM) plays a crucial role in the regulation of tumor growth and progression. In the lungs, fibroblasts are involved in ECM homeostasis and are therefore crucial in lung tissue repair and remodeling. These activities are exploited by cancer cells during tumor growth by reprogramming fibroblast towards a tumor supportive phenotype including regulation of ECM-related proteins. We previously identified the nuclear transported...