High-Throughput Metabolomics Method for Discovering Metabolic Biomarkers and Pathways to Reveal Effects and Molecular Mechanism of Ethanol Extract From Epimedium Against Osteoporosis

Metabolomics is an effective strategy to explore the molecular mechanism of herbal medicine. Epimedium, a traditional Chinese herb, has a therapeutic effect on osteoporosis (OP), however the molecular mechanism of the anti-OP effect of epimedium is still little known. In this study, we investigated the pharmacological effect and action mechanism of ethanol extract of epimedium (Ext-epi) on OP rat model by metabolomics method for discovering...