Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734.
Abstract
Bromodomain and extra-terminal domain (BET) proteins, cyclic adenosine monophosphate response element-binding protein (CBP), and the E1A-binding protein of p300 (EP300) are important players in histone acetylation. Preclinical evidence supports the notion that small molecules targeting these proteins individually or in combination can elicit antitumor activity. Here, we characterize the antitumor activity of the pan BET/CBP/EP300 inhibitor...
Paper Details
Title
Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734.
Published Date
Sep 8, 2020
Journal
Volume
4
Issue
17
Pages
4124 - 4135
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