Modulation of the Intracrine Renin Angiotensin System in Mesangial Cells Submitted to Aldosterone Stimulus

Currently it's well known that the classic pathway Renin/Angiotensin converting enzyme (ACE)/Angiotensin II (Ang II)/receptors AT1/AT2 it's not the only effective signalization path where the Renin‐Angiotensin‐Aldosterone System (RAAS) can act. Three new paths were described recently: ACE2/Ang (1–7)/receptor Mas, prorenin(PRR)/MAPKinasesERK1/2 e Ang IV/AT4/Insulin regulated aminopeptidase (IRAP). The identification of a local RAAS components...