Drug resistance

Internal medicine

Klebsiella pneumonia

Antibiotics

Bacteria

Escherichia coli

Biology

Microbiology

Gene

Multiple drug resistance

Virology

Pathogen

Klebsiella pneumoniae

Pseudomonas aeruginosa

Pneumonia

Bacteremia

Genetics

Biofilm

Virulence

Medicine

Antibiotic resistance

International Journal of Environmental Research and Public Health

Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. With the emergence of multidrug-resistant (MDR) and hypervirulent K. pneumoniae (hvKP) strains, the rapid spread of these clinical strains in geography is particularly worrying. However, the detailed mechanisms of virulence and antibiotic resistance in K. pneumoniae are still not very clear. Therefore, studying and elucidating the pathogenic mechanisms and drug resistance mechanism of K. pneumoniae infection are important parts of current medical research. In this paper, we systematically summarized the virulence, biofilm, and antibiotic tolerance mechanisms of K. pneumoniae, and explored the application of whole genome sequencing and global proteomics, which will provide new clues for clinical treatment of K. pneumoniae.

The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae