Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Volume: 23, Issue: 9, Pages: 101470 - 101470
Published: Sep 1, 2020
Abstract
•TGF-β promotes prostate cancer cell migration and invasion, via Smad7•Lysine 102 in Smad7 binds to DNA in regulatory regions of HDAC6 and c-Jun•Smad7 regulates expression of HDAC6 and c-Jun in prostate cancer in response to TGF-β•High levels of Smad7, c-Jun, and HDAC6 are found in aggressive prostate cancer tissues Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7...
Paper Details
Title
Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
Published Date
Sep 1, 2020
Journal
Volume
23
Issue
9
Pages
101470 - 101470
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