IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER
Volume: 319, Issue: 4, Pages: E734 - E743
Published: Oct 1, 2020
Abstract
Autophagy dysfunctions are involved in the pathogenesis of Parkinson’s disease (PD). In the present study, we aimed to evaluate the involvement of G protein-coupled estrogen receptor (GPER) in the inhibitory effect of insulin-like growth factor-1 (IGF-1) against excessive autophagy in PD animal and cellular models. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment significantly induced mouse movement disorder and decreased the...
Paper Details
Title
IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER
Published Date
Oct 1, 2020
Volume
319
Issue
4
Pages
E734 - E743
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