Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair
Abstract
Macrophages are a primary immune cell involved in inflammation, and their cell plasticity allows for transition from an inflammatory to a reparative phenotype and is critical for normal tissue repair following injury. Evidence suggests that epigenetic alterations play a critical role in establishing macrophage phenotype and function during normal and pathologic wound repair. Here, we find in human and murine wound macrophages that cyclooxygenase...
Paper Details
Title
Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair
Published Date
Sep 3, 2020
Journal
Volume
5
Issue
17
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Notes
History