Pea ‐derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS‐1/PI3K/AKT and blocking ROS‐mediated p38MAPK signaling
Abstract
This study evaluated the effect of four peptides, VLP, LLP, LL, and LL from pea on regulating glucose metabolism and antioxidant through IRS-1/PI3K/AKT and p38MAPK signal pathway in IR-HepG2 cell induced by 10-6M insulin. The genes expression of PEPCK, G6Pase, GLUT2, and IRS-1 and proteins of IRS-1, p(Ser307)-IRS-1, AKT, p(Ser473)-AKT, p38MAPK, and p-p38MAPK were determined by RT-PCR and western blotting, respectively. Results show that they...
Paper Details
Title
Pea ‐derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS‐1/PI3K/AKT and blocking ROS‐mediated p38MAPK signaling
Published Date
Sep 2, 2020
Journal
Volume
44
Issue
11
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