Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
Abstract
Increased extracellular sodium activates Th17 cells, which provide protection from bacterial and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease, the immunological consequences of clinical salt depletion are unknown. Here, we investigate immunity in patients with inherited salt-losing tubulopathies (SLT). Forty-seven genotyped SLT patients (with Bartter, Gitelman or EAST Syndromes) are recruited. Clinical...
Paper Details
Title
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
Published Date
Aug 31, 2020
Journal
Volume
11
Issue
1
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