Directional Mast Cell Degranulation of TNF into Blood Vessels Primes Neutrophil Extravasation
Abstract
Tissue resident mast cells (MCs) rapidly initiate neutrophil infiltration upon inflammatory insult, yet the molecular mechanism is still unknown. Here, we demonstrate that MC-derived TNF is crucial for neutrophil extravasation to sites of sterile skin inflammation by promoting intraluminal adhesion and crawling. Strikingly, MC-TNF directly primes circulating neutrophils via TNFR1, while being dispensable for chemokine production and endothelial...
Paper Details
Title
Directional Mast Cell Degranulation of TNF into Blood Vessels Primes Neutrophil Extravasation
Published Date
Jan 1, 2020
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