Vagal α7nAChR signaling regulates α7nAChR+Sca1+ cells during lung injury repair

Background The distal airways of the lung and bone marrow are innervated by the vagus nerve. Vagal α7nAChR signaling plays a key role in regulating lung infection and inflammation; however, whether this pathway regulates α7nAChR + Sca1 + cells during lung injury repair remains unknown. We hypothesized that vagal α7nAChR signaling controls α7nAChR + Sca1 + cells, which contribute to the resolution of lung injury. Methods Pneumonia was induced by...