Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure in patients regardless of the presence or absence of diabetes. More evidence is needed regarding the effects of these drugs in patients across the broad spectrum of heart failure, including those with a markedly reduced ejection fraction.In this double-blind trial, we randomly assigned 3730 patients with class II, III, or IV heart failure and...