Selectivity

Organic chemistry

Combinatorial chemistry

Stereochemistry

Engineering

Catalysis

Natural rubber

Stereoselectivity

Biochemical engineering

Chemistry

Natural product

Diene

Total synthesis

Advanced Synthesis & Catalysis

The E,Z ‐configured 1,3‐diene unit is a common motif in numerous bioactive natural products. Although several powerful methods are available to produce these motifs with high levels of selectivity, their construction within a complex, polyfunctionalised structure, such as a natural product, requires well‐defined strategies to avoid undesirable reactions and low‐to‐moderate selectivities. The aim of this review is to provide a full account of the stereoselective strategies for building E,Z ‐configured 1,3‐dienes, as well as to highlight selected total syntheses that employ them. magnified image

Stereoselective Construction of (<i>E,Z</i>)‐1,3‐Dienes and Its Application in Natural Product Synthesis

Stereoselective Construction of (E,Z)‐1,3‐Dienes and Its Application in Natural Product Synthesis