Sclerostin‐Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters
Volume: 36, Issue: 1, Pages: 158 - 169
Published: Sep 23, 2020
Abstract
Obesity, a growing pandemic, is a risk factor for many cancers and causes increased bone marrow adipose tissue (BMAT). in vitro studies and obese animal models suggest that BMAT contributes to cancer progression, but there is a lack of preclinical models to directly test BMAT's role in cancer. Overactivation of peroxisome-proliferator-activated receptor-γ (PPARγ) can skew bone formation and resorption rates, resulting in increased BMAT and...
Paper Details
Title
Sclerostin‐Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters
Published Date
Sep 23, 2020
Volume
36
Issue
1
Pages
158 - 169
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