VEGF-C protects the integrity of the bone marrow perivascular niche in mice
Abstract
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC regulatory signals. Radiation and chemotherapy disrupt the HSC niche, including its sinusoidal vessels and perivascular cells, contributing to delayed hematopoietic recovery. Thus, identification of factors that can protect the HSC niche during an injury could offer a significant therapeutic opportunity to improve hematopoietic...
Paper Details
Title
VEGF-C protects the integrity of the bone marrow perivascular niche in mice
Published Date
Oct 15, 2020
Journal
Volume
136
Issue
16
Pages
1871 - 1883
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