Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen
Abstract
This study investigated the effect of binder level on the physicochemical changes and tabletability of acetaminophen (APAP)-hydroxypropyl cellulose (HPC) granulated using twin-screw melt granulation. Even at 5% HPC level, the tablet tensile strength achieved up to 3.5 MPa. A minimum of 10% HPC was required for the process robustness. However, 20% HPC led to tabletability loss, attributable to the high mechanical strength of APAP granules. The...
Paper Details
Title
Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen
Published Date
Aug 24, 2020
Journal
Volume
21
Issue
7
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History