Noninvasive Evaluation of CD20 Expression Using ⁶⁴Cu-Labeled F(ab′)₂ Fragments of Obinutuzumab in Lymphoma

CD20-overexpressed non-Hodgkin lymphoma typically indicates progressive malignancy. Obinutuzumab is a next-generation Food and Drug Administration–approved humanized monoclonal antibody that targets CD20. Previous studies with ⁸⁹Zr-labeled obinutuzumab have successfully imaged CD20 in vivo. However, delayed tumor uptake and increased radioactive exposure caused by long blood circulation limit its clinical translation. This study aimed...