Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures.

Published on Aug 27, 2020
· DOI :10.3390/BIOM10091242
Daniela Bispo1
Estimated H-index: 1
Victoria T. Fabris10
Estimated H-index: 10
+ 3 AuthorsAna M. Gil44
Estimated H-index: 44
#1Juntong Wei (Hong Kong Baptist University)H-Index: 11
#2Xiaona Li (Hong Kong Baptist University)H-Index: 7
Last. Zongwei Cai (Hong Kong Baptist University)H-Index: 58
view all 7 authors...
Abstract Polybrominated diphenyl ether-47 (BDE-47) is a congener of polybrominated diphenyl ethers (PBDEs) and relates to different health risks. However, in vivo study of the association between BDE-47 and breast cancer was scarce. In this study, we performed in vivo exposure of BDE-47 to breast cancer nude mice and conducted mass spectrometry-based metabolomics and lipidomics analysis to investigate the metabolic changes in mice. Results showed that the tumor sizes were positively associated w...
4 CitationsSource
#1Ryan T. Davis (UCI: University of California, Irvine)H-Index: 4
#2Kerrigan Blake (UCI: University of California, Irvine)H-Index: 2
Last. Devon A. Lawson (UCI: University of California, Irvine)H-Index: 22
view all 18 authors...
Although metastasis remains the cause of most cancer-related mortality, mechanisms governing seeding in distal tissues are poorly understood. Here, we establish a robust method for the identification of global transcriptomic changes in rare metastatic cells during seeding using single-cell RNA sequencing and patient-derived-xenograft models of breast cancer. We find that both primary tumours and micrometastases display transcriptional heterogeneity but micrometastases harbour a distinct transcri...
30 CitationsSource
#1Rita Araújo (University of Aveiro)H-Index: 17
#1Rita Araújo (University of Aveiro)H-Index: 2
Last. Ana M. Gil (University of Aveiro)H-Index: 44
view all 4 authors...
Abstract Background Metabolomic strategies have been extensively used to search for biomarkers of disease, including cancer, in biological complex mixtures such as cells, tissues and biofluids. In breast cancer research, murine models are of great value and metabolomics has been increasingly applied to characterize tumor or organ tissues, or biofluids, for instance to follow-up metabolism during cancer progression or response to specific therapies. Scope of review This review briefly introduces ...
2 CitationsSource
#1Ying-Chen Huang (NTU: National Taiwan University)H-Index: 2
#1Ying-Chen Huang (NTU: National Taiwan University)H-Index: 1
Last. Cheng-Chih Hsu (NTU: National Taiwan University)H-Index: 19
view all 8 authors...
Paper spray ionization has been used as a fast sampling/ionization method for the direct mass spectrometric analysis of biological samples at ambient conditions. Here, we demonstrated that by utilizing paper spray ionization mass spectrometry (PSI-MS) coupled with field asymmetric waveform ion mobility spectrometry (FAIMS), predictive metabolic and lipidomic profiles of routine breast core needle biopsies could be obtained effectively. By the combination of machine learning and pathological exam...
9 CitationsSource
#1Ana S. Dias (University of Aveiro)H-Index: 11
#2Catarina R. Almeida (University of Aveiro)H-Index: 21
Last. Iola F. Duarte (University of Aveiro)H-Index: 32
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Abstract During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and fatty acid biosynthesis. However, the extension and functional importance of these metabolic alterations may diverge not only according to breast cancer subtypes, but also depending on the interaction of cancer cells with the complex surrounding microenvironment. This microenvironment comprises a variety of non-can...
32 CitationsSource
#1Qi ZhangH-Index: 23
#2Yu LouH-Index: 10
Last. Xueli BaiH-Index: 26
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Objective Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, which decreases the efficacy of clinical treatments. Understanding tumour heterogeneity is critical when developing novel treatment strategies. However, a comprehensive investigation of tumour heterogeneity in HCC is lacking, and the available evidence regarding tumour heterogeneity has not led to improvements in clinical practice. Design We harvested 42 samples from eight HCC patients and evaluated tumo...
53 CitationsSource
#1Amy E. McCart Reed (UQ: University of Queensland)H-Index: 14
#2Priyakshi Kalita-de Croft (UQ: University of Queensland)H-Index: 7
Last. Sunil R. Lakhani (UQ: University of Queensland)H-Index: 82
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During the last decade, the genomics revolution has driven critical advances in molecular oncology and pathology, and a deeper appreciation of heterogeneity that is beginning to reshape our thinking around diagnostic classification. Recent developments have seen existing classification systems modified and improved where possible, gene-based diagnostics implemented and tumour-immune interactions modulated. We present a detailed discussion of this progress, including the advances in understanding...
17 CitationsSource
#1Florian P.Y. Barré (UM: Maastricht University)H-Index: 6
#2Britt S R Claes (UM: Maastricht University)H-Index: 3
Last. Berta Cillero-Pastor (UM: Maastricht University)H-Index: 16
view all 10 authors...
Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma. To treat this aggressive disease, R-CHOP, a combination of immunotherapy (R; rituximab) and chemotherapy (CHOP; cyclophosphamide, doxorubicin, vincristine, and prednisone), remains the most commonly used regimen for newly diagnosed DLBCLs. However, up to one-third of patients ultimately becomes refractory to initial therapy or relapses after treatment, and the high mortality rate highlights the urgent need for ...
11 CitationsSource
#1Anup Kumar Paul (SGPGIMS: Sanjay Gandhi Post Graduate Institute of Medical Sciences)H-Index: 6
#1Anup Paul (LU: University of Lucknow)H-Index: 1
Last. Raja RoyH-Index: 30
view all 7 authors...
Introduction Breast cancer is the most frequent diagnosed cancer among women with a mortality rate of 15% of all cancer related deaths in women. Breast cancer is heterogeneous in nature and produces plethora of metabolites allowing its early detection using molecular diagnostic techniques like magnetic resonance spectroscopy.
6 CitationsSource
#2Susan CostantiniH-Index: 33
Last. Lorella SeverinoH-Index: 17
view all 8 authors...
Introduction Zearalenone (ZEN) is one of the most widely distributed toxins that contaminates many crops and foods. Its major metabolites are α-Zearalenol (α-zol) and β-Zearalenol. Previous studies showed that ZEN and α-zol have estrogenic properties and are able to induce growth promoting effect in breast tissues.
5 CitationsSource
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