DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
Abstract
Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years. DNA double-strand breaks (DSB) bear the greatest risk of provoking genomic instability, and DNA damage repair (DDR) pathways are crucial in preserving genomic integrity following a plethora of damage types. Two major repair pathways dominate DSB repair...
Paper Details
Title
DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
Published Date
Aug 27, 2020
Journal
Volume
70
Issue
3
Pages
606 - 617
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