Spatially resolved estimation of metabolic oxygen consumption from optical measurements in cortex

Significance: The cerebral metabolic rate of oxygen (CMRO2) is an important indicator of brain function and pathology. Knowledge about its magnitude is also required for proper interpretation of the blood oxygenation level-dependent (BOLD) signal measured with functional MRI. Despite the need for estimating CMRO2, no gold standard exists. Traditionally, the estimation of CMRO2 has been pursued with somewhat indirect approaches combining several...