Abstract 5688: IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology
Abstract
ONC201 is the first clinical bitopic antagonist of dopamine receptor D2 (DRD2), that is well tolerated and induces durable tumor regressions in H3 K27M-mutant glioma patients. ONC206, a derivative of ONC201 that shares the imipridone core structure, is also a bitopic DRD2 antagonist that exhibits enhanced non-competitive effects, high specificity, nanomolar potency, and disruption of DRD2 homodimers. ONC206 exhibited a Ki of ~320nM for DRD2 with...
Paper Details
Title
Abstract 5688: IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology
Published Date
Aug 15, 2020
Journal
Volume
80
Issue
16_Supplement
Pages
5688 - 5688
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