Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Preeclampsia (PE) is an obstetric disorder with significant morbidities for both the mother and fetus possibly caused by a failure of the placental trophoblast invasion. However, its pathophysiology largely remains unclear. Here, we performed DNA methylation profiling to determine whether differential patterns of DNA methylation correlate with PE and severe features of PE.We extracted DNA from placental tissues of 13 normal, five PE, and eight...